Posted on: September 26, 2020 Posted by: Jonathan Comments: 0
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Vital Zr isotope variations in single zircon grains recording magma evolution historical past

 

Zircons extensively happen in magmatic rocks and sometimes show inner zonation finely recording the magmatic historical past. Right here, we offered in situ high-precision (2SD <0.15‰ for δ94Zr) and high-spatial-resolution (20 µm) steady Zr isotope compositions of magmatic zircons in a collection of calc-alkaline plutonic rocks from the juvenile a part of the Gangdese arc, southern Tibet.

These zircon grains are internally zoned with Zr isotopically mild cores and more and more heavier rims. Our information recommend the preferential incorporation of lighter Zr isotopes in zircon from the soften, which might drive the residual soften to heavier values. The Rayleigh distillation mannequin can properly clarify the noticed inner zoning in single zircon grains, and the best-fit fashions gave common zircon-melt fractionation components for every pattern starting from 0.99955 to 0.99988.

The common fractionation components are positively correlated with the median Ti-in-zircon temperatures, indicating a robust temperature dependence of Zr isotopic fractionation. The outcomes display that in situ Zr isotope analyses could be one other highly effective contribution to the geochemical toolbox associated to zircon. The findings of this examine remedy the basic difficulty on how zircon fractionates Zr isotopes in calc-alkaline magmas, the main sort of magmas that led to forming continental crust over time. The outcomes additionally present the good potential of steady Zr isotopes in tracing magmatic thermal and chemical evolution and thus presumably continental crustal differentiation.

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Human DKK-1 ELISA Kit

EK5390 96 tests
EUR 599

DKK-1 ELISA KIT|Human

EF000090 96 Tests
EUR 826.8

Human Dkk-1 ELISA Kit

E28L0566 96T
EUR 666.67

Human Dkk-1 ELISA KIT

E42EH-269 96T/48T Ask for price

Human DKK-1 ELISA kit

LF-EK50797 1×96T
EUR 777.6

Human Dkk-1 ELISA Kit

GWB-SKR221 96 Tests Ask for price

Human CellExp? DKK-1, Human Recombinant

7132-10 each
EUR 333.6

Human CellExp? DKK-1, Human Recombinant

7132-50 each
EUR 1358.4

DKK-1 (HEK293-expressed), Human

HY-P7155A 50ug
EUR 1011.6

human Dkk-1 Recombinant Protein

100-407 10 µg
EUR 196.35
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

human Dkk-1 Recombinant Protein

100-407S 2 µg
EUR 92.4
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

Human Dkk-1 Recombinant Protein

200-013 20 µg
EUR 136.5
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

Human Dkk-1 Recombinant Protein

200-013S 5 µg
EUR 92.4
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

Recombinant Human DKK-1 Protein

PROTO94907-3 10ug
EUR 380.4
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

Dkk-1

GT30000 50 ug
EUR 631.2

Human DKK Antibody

E63C02401 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Human DKK-1 PicoKine ELISA Kit

EK0867 96 wells
EUR 510
Description: For quantitative detection of human DKK1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Active Recombinant Human Dkk-1 Protein

RP01343 100μg
EUR 162.5

Human DKK-1 Recombinant Protein Lyophilized

IHUDKK1RLY2UG each
EUR 341
Description: Human DKK-1 Recombinant Protein Lyophilized

Human DKK-1 ELISA kit (4×96T)

LF-EK50798 4×96T
EUR 2641.2

Nori® Human DKK-1 ELISA Kit

GR106268 96-well
EUR 461

DKK-1 Antibody

F51803-0.4ML 0.4 ml
EUR 322.15
Description: DKK-1 is a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK-1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

OKRC00363-96W - Dkk-1 ELISA Kit (Human)

OKRC00363-96W 96Wells
EUR 525

OKAG00221-96W - Dkk-1 ELISA Kit (Human)

OKAG00221-96W 1plate:12x8-WellMicrostrips
EUR 475

Human DKK Antibody-HRP

E63C02402 100ug/100ul
EUR 275
Description: Available in various conjugation types.

DKK-3 ELISA KIT|Human

EF000091 96 Tests
EUR 826.8

Human DKK Antibody-BIOTIN

E63C02403 100ug/100ul
EUR 275
Description: Available in various conjugation types.

Recombinant Human DKK1/Dkk-1 Protein (His Tag)

PKSH033697-10ug 10ug
EUR 178
Description: Human

Recombinant Human DKK1/Dkk-1 Protein (His Tag)

PKSH033697-50ug 50ug
EUR 523
Description: Human

human Dkk-3 Recombinant Protein

100-408 10 µg
EUR 196.35
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-l1 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains.  Playing an important regulatory role in vertebrate development through localized inhibition of Wnt regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-3 has been shown to potentiate, rather than inhibit, Wnt signaling through interactions with the high-affinity, transmembrane coreceptors Kremen-1 (Krm1) and Kremen-2 (Krm2). Recombinant human DKK-3 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 36.3 kDa and contains 329 amino acid residues. Due to glycosylation, human DKK-3 migrates at an apparent molecular weight of approximately 39-49 kDa by SDS-PAGE analysis under non-reducing conditions.

human Dkk-3 Recombinant Protein

100-408S 2 µg
EUR 92.4
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-l1 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains.  Playing an important regulatory role in vertebrate development through localized inhibition of Wnt regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-3 has been shown to potentiate, rather than inhibit, Wnt signaling through interactions with the high-affinity, transmembrane coreceptors Kremen-1 (Krm1) and Kremen-2 (Krm2). Recombinant human DKK-3 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 36.3 kDa and contains 329 amino acid residues. Due to glycosylation, human DKK-3 migrates at an apparent molecular weight of approximately 39-49 kDa by SDS-PAGE analysis under non-reducing conditions.

human Dkk-2 Recombinant Protein

100-436 10 µg
EUR 196.35
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 25.8 kDa and contains 234 amino acid residues. Due to glycosylation, human DKK-2 migrates at an apparent molecular weight of approximately 31-36 kDa by SDS-PAGE analysis under non-reducing conditions.

human Dkk-2 Recombinant Protein

100-436S 2 µg
EUR 92.4
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 25.8 kDa and contains 234 amino acid residues. Due to glycosylation, human DKK-2 migrates at an apparent molecular weight of approximately 31-36 kDa by SDS-PAGE analysis under non-reducing conditions.

Human Dkk-2 Recombinant Protein

200-014 20 µg
EUR 136.5
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 fused to a C terminal His-tag derived from E. coli has a molecular weight of 26.0 kDa and contains 234 amino acid residues.

Human Dkk-2 Recombinant Protein

200-014S 5 µg
EUR 92.4
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 fused to a C terminal His-tag derived from E. coli has a molecular weight of 26.0 kDa and contains 234 amino acid residues.

Recombinant Human Dkk-3 Protein

RP00209 10 μg
EUR 97.5

Recombinant Human Dkk-3 Protein

RP00355 10 μg
EUR 196.8

Anti-Human Dkk-1 Antibody

102-PA33 200 µg
EUR 204.75
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

Anti-Human Dkk-1 Antibody

102-PA33S 100 µg
EUR 126
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

Anti-Human Dkk-1 Antibody

101-M380 100 µg
EUR 399
Description: Dkk1 is a Dickkopf-related protein that inhibits Wnt signaling by binding the Wnt coreceptor LRP5/6. It also binds Kremen1 and Kremen2. Dkk1 is important in embryonic development.

Anti-Human Dkk-1 Antibody

101-M426 100 µg
EUR 399
Description: Dkk1 is a Dickkopf-related protein that inhibits Wnt signaling by binding the Wnt coreceptor LRP5/6. It also binds Kremen1 and Kremen2. Dkk1 is important in embryonic development.

Human Dkk-1 Protein, Fc Tag (MALS verified)

DK1-H5258 1mg
EUR 310.3
Description: Human Dkk-1, Fc Tag (DK1-H5258) is expressed from human 293 cells (HEK293). It contains AA Thr 32 - His 266 (Accession # NP_036374.1).

Dkk-1 ELISA Kit (Human) : 96 Wells (OKAG00221)

OKAG00221 96 Wells
EUR 715.2
Description: Description of target: This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.;Species reactivity: Human;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 63 pg/mL

Human Dkk-1 Protein, His Tag, premium grade

DK1-H5221 1mg
EUR 139.1
Description: Human Dkk-1 Protein, His Tag, premium grade (DK1-H5221) is expressed from human 293 cells (HEK293). It contains AA Thr 32 - His 266 (Accession # NP_036374.1).

Biotinylated Human Dkk-1 Protein, Fc,Avitag™

DK1-H82F5 25ug
EUR 1487.3
Description: Biotinylated Human Dkk-1, Fc,Avitag (DK1-H82F5) is expressed from human 293 cells (HEK293). It contains AA Thr 32 - His 266 (Accession # O94907-1).

Human DKK-1(Dickkopf-related protein 1) ELISA Kit

EH0113 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Human DKK-1(Dickkopf-related protein 1) ELISA Kit

EKF57029-48T 48T
EUR 396.9

Human DKK-1(Dickkopf-related protein 1) ELISA Kit

EKF57029-5x96T 5x96T
EUR 2693.25

Human DKK-1(Dickkopf-related protein 1) ELISA Kit

EKF57029-96T 96T
EUR 567

Rabbit Anti Human DKK PcAb

E61C02403 100ug
EUR 225
Description: Available in various conjugation types.

Rabbit Anti Human DKK PcAb

E61C02403a 1mg
EUR 1125
Description: Available in various conjugation types.

Dkk-1 Rabbit pAb

E2251891 100ul
EUR 225
Description: Available in various conjugation types.

Recombinant Human DKK-1/DKK1 Protein, 8* His Tag

E40KMH986 20ug
EUR 495

Human DKK-2 Protein, His Tag

DK2-H5323 1mg
EUR 224.7
Description: Human DKK-2 Protein, His Tag (DK2-H5323) is expressed from CHO cells. It contains AA Lys 34 - Ile 259 (Accession # Q9UBU2).

Recombinant Human DKK1/Dkk-1 Protein (His Tag)(Active)

PKSH031807-100ug 100ug
EUR 636
Description: Human

Recombinant Human DKK1/Dkk-1 Protein (His Tag)(Active)

PKSH031807-20ug 20ug
EUR 303
Description: Human

Human DKK-4 PicoKine ELISA Kit

EK0868 96 wells
EUR 546
Description: For Quantitative Detection of human DKK-4 in cell culture supernates, serum and plasma(heparin, EDTA).

Human DKK-3 PicoKine ELISA Kit

EK1323 96 wells
EUR 510
Description: For quantitative detection of human DKK-3 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Dkk-1 Polyclonal Antibody

41928-100ul 100ul
EUR 302.4

Dkk-1 Polyclonal Antibody

41928-50ul 50ul
EUR 224.4

DKK-1 Recombinant Protein

40-225-0002mg 0.002 mg
EUR 311.1
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

DKK-1 Recombinant Protein

40-225-001mg 0.01 mg
EUR 437.1
Description: DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

Dkk-1 Polyclonal Antibody

E041928 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Dkk-1 Polyclonal Antibody

E20-75562 100ug
EUR 225
Description: Available in various conjugation types.

Dkk-1 Polyclonal Antibody

ABP53293-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1

Dkk-1 Polyclonal Antibody

ABP53293-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1

Dkk-1 Polyclonal Antibody

ABP53293-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Dkk-1 from Human, Mouse, Rat. This Dkk-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Dkk-1

Dkk-1 Recombinant Protein

96-861 0.1 mg
EUR 651.3
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via beta-catenin mediated Pdgfralpha and E-cadherin expression.

Dkk-1 Recombinant Protein

96-990 0.05 mg
EUR 714.3
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via beta-catenin mediated Pdgfralpha and E-cadherin expression.

Dkk-1 Polyclonal Antibody

E44H07004 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

DKK-3 ELISA Kit (Human) (OKBB00603)

OKBB00603 96 Wells
EUR 606
Description: Description of target: Dickkopf-related protein 3 is a protein that in humans is encoded by the DKK3 gene. This gene encodes a protein that is a member of the dickkopf family. It is mapped to 11p15.3. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Members of the Dkk-related family display unique patterns of mRNA expression in human and mouse tissues, and are secreted when expressed in 293T cells. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL

Nori® Human DKK-1 ELISA Kit (2 plates)

GR106268-2 2 x 96-well
EUR 832

Dkk-2

GT15222 100 ug
EUR 631.2

Human DKK-2 Recombinant Protein Lyophilized

IHUDKK2RLY2UG each
EUR 317
Description: Human DKK-2 Recombinant Protein Lyophilized

Human DKK-3 Recombinant Protein Lyophilized

IHUDKK3RLY2UG each
EUR 317
Description: Human DKK-3 Recombinant Protein Lyophilized

Mouse Monoclonal anti-human Dkk-1

hAP-0246 100ug
EUR 250

Mouse Monoclonal anti-human Dkk-1

hAP-0246A 100ug
EUR 250

Sheep Polyclonal anti-Human Dkk-1

hAP-5846 50ug
EUR 400

Biotinylated Recombinant Human Dkk-3 Protein

RP02554 100μg
EUR 1423.5

Recombinant Human Dickkopf-Related Protein 1/DKK-1 (C-Fc)

PKSH034024-10ug 10ug
EUR 100
Description: Human

Recombinant Human Dickkopf-Related Protein 1/DKK-1 (C-Fc)

PKSH034024-50ug 50ug
EUR 300
Description: Human

Human Dkk-3 (R335G) Protein, His Tag

DK3-H5220 20ug
EUR 460.1
Description: Human Dkk-3 (R335G), His Tag (DK3-H5220) is expressed from human 293 cells (HEK293). It contains AA Ala 22 - Ile 350 (Accession # Q9UBP4-1 (R335G)).

DKK 1 Recombinant Protein

96-236 0.1 mg
EUR 752.1
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.

DKK 1 Recombinant Protein

96-237 0.025 mg
EUR 619.8
Description: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.

Rat DKK-1 ELISA Kit

EK5668 96 tests
EUR 599

Mouse Dkk-1 ELISA Kit

E28L0661 96T
EUR 666.67

Mouse Dkk-1 ELISA KIT

E42EM-173 96T/48T Ask for price

OKRC00364-96W - Dkk-3 ELISA Kit (Human)

OKRC00364-96W 96Wells
EUR 525

OKRC00365-96W - Dkk-4 ELISA Kit (Human)

OKRC00365-96W 96Wells
EUR 525

OKBB00603-96W - DKK-3 ELISA Kit (Human)

OKBB00603-96W 96Wells
EUR 538

DKK-1 (CHO-expressed), Mouse

HY-P7154 50ug
EUR 914.4

Dkk-1 Rabbit Polyclonal Antibody

ES4292-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Dkk-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Dkk-1 Rabbit Polyclonal Antibody

ES4292-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Dkk-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Recombinant Human DKK-3/DKK3 Protein, His Tag

E40KMH988 20ug
EUR 495

Recombinant Human Dkk-3/DKK3 Protein, His Tag

E40KMP1519 20ug
EUR 495

Dkk-1 Polyclonal Conjugated Antibody

C41928 100ul
EUR 476.4

Dkk-3 antibody

22898 100ul
EUR 479

Dkk-3 antibody

22898-100ul 100ul
EUR 468

Anti-Human Dkk-2 Antibody

102-PA34 200 µg
EUR 204.75
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 fused to a C terminal His-tag derived from E. coli has a molecular weight of 26.0 kDa and contains 234 amino acid residues.

Anti-Human Dkk-2 Antibody

102-PA34S 100 µg
EUR 126
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 fused to a C terminal His-tag derived from E. coli has a molecular weight of 26.0 kDa and contains 234 amino acid residues.

Anti-Human Dkk-3 Antibody

101-M470 100 µg
EUR 399
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-l1 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains.  Playing an important regulatory role in vertebrate development through localized inhibition of Wnt regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-3 has been shown to potentiate, rather than inhibit, Wnt signaling through interactions with the high-affinity, transmembrane coreceptors Kremen-1 (Krm1) and Kremen-2 (Krm2). Recombinant human DKK-3 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 36.3 kDa and contains 329 amino acid residues. Due to glycosylation, human DKK-3 migrates at an apparent molecular weight of approximately 39-49 kDa by SDS-PAGE analysis under non-reducing conditions.

Anti-Human Dkk-4 Antibody

101-M491 100 µg
EUR 399
Description: Dickkopf related protein 4 (Dkk4) is a member of the Dkk protein family that includes Dkk1, 2, 3, and 4. All four members are secreted proteins that are synthesized as precursor proteins with an Nterminal signal peptide and 2 conserved cysteinerich domains, which are separated by a linker region. Dkk proteins have potential furin type proteolytic cleavage sites, and short forms of Dkk2 and Dkk4 containing only the second cysteine-rich domain can be generated by proteolytic processing. Dkk proteins have distinct patterns of expression in adult and embryonic tissues, suggesting that they may play diverse roles in these tissues. The Dkk proteins have distinct effects on Wnt signaling. Dkk1 and Dkk4 are Wnt antagonists. Dkk3 has not been demonstrated to affect Wnt signaling, and Dkk2 acts as an agonist or antagonist, depending on the cellular context.

Mouse Dkk-1 Protein, His Tag

DK1-M52H6 500ug
EUR 374.5
Description: Mouse Dkk-1, His Tag (DK1-M52H6) is expressed from human 293 cells (HEK293). It contains AA Thr 32 - His 272 (Accession # O54908).

Active Recombinant Mouse Dkk-1 Protein

RP01350LQ 100μg
EUR 243.75

Active Recombinant Mouse Dkk-1 Protein

RP01062 5 μg
EUR 390

Recombinant Human Dickkopf-Related Protein 1/DKK-1 (C-Avi-6His) Biotinylated

PKSH034043-100ug 100ug
EUR 924
Description: Human

Recombinant Human Dickkopf-Related Protein 1/DKK-1 (C-Avi-6His) Biotinylated

PKSH034043-20ug 20ug
EUR 342
Description: Human

Recombinant Human DKK-2/DKK2 Protein, Fc Tag & His Tag.

E40KMH987 20ug
EUR 495

Dkk Polyclonal Antibody

41928 100ul
EUR 319

Human DKK-3(Dickkopf-related protein 3) ELISA Kit

EH0114 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 37.5pg/ml

Human DKK-3(Dickkopf-related protein 3) ELISA Kit

EKF60378-48T 48T
EUR 396.9

Human DKK-3(Dickkopf-related protein 3) ELISA Kit

EKF60378-5x96T 5x96T
EUR 2693.25

Human DKK-3(Dickkopf-related protein 3) ELISA Kit

EKF60378-96T 96T
EUR 567

DKK-2 Recombinant Protein

40-651 2 ug
EUR 311.1
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 25.8 kDa and contains 234 amino acid residues. Due to glycosylation, human DKK-2 migrates at an apparent molecular weight of approximately 31-36 kDa by SDS-PAGE analysis under non-reducing conditions.

DKK-3 Recombinant Protein

40-652 2 ug
EUR 311.1
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-L1 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-3 has been shown to potentiate, rather than inhibit, Wnt signaling through interactions with the high-affinity, transmembrane co-receptors Kremen-1 (Krm1) and Kremen-2 (Krm2). Recombinant Human DKK-3 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 36.3 kDa and contains 329 amino acid residues. Due to glycosylation, Human DKK-3 migrates at an apparent molecular weight of approximately 39-49 kDa by SDS-PAGE analysis under non-reducing conditions.

 

 

Ab initio quantum chemical research of isotopic fractionation throughout acid digestion response of dolomite for clumped isotope software

 

acid to extract CO2 that carries the isotopic signature of the reacting carbonates, and the quantity of clumping within the product CO2 is measured. Earlier theoretical fashions for figuring out clumped isotopic fractionation in product CO2 throughout acid digestion of carbonates are impartial of the cations current within the carbonate lattice. Therefore additional examine is required to know the cationic impact.

Strategies: We studied the acid response mechanism primarily based on the protonation of carbonates, calculated the acid fractionation factor for dolomite utilizing the partition features and vibrational frequencies obtained for the transition state construction, and decided the impact of cations on the acid fractionation issue. Experimentally carbonates are reacted utilizing the modified sealed vessel methodology and analyzed within the dual-inlet of a ThermoFinnigan MAT 253 isotope ratio mass spectrometer.

Outcomes: Theoretically obtained acid fractionation issue could be expressed as Δ47 acid fractionation in dolomite = -0.28563 + 0.49508*(105 / T2 ) – 0.08231* (105 /T2 )2 for a temperature vary between 278.15 Okay and 383.15 Okay. The theoretical slope of the dolomite-acid digestion curve is decrease than that of the calcite-acid digestion curve obtained utilizing the an identical response mechanism. Our theoretical slope is in keeping with the end result from the frequent acid bathtub experiments however greater than the slope obtained in our experimental examine utilizing the modified sealed vessel methodology and in a earlier theoretical examine utilizing the H2 CO3 mannequin.

Conclusions: The transition state construction, obtained in our examine, contains the cations current within the carbonate minerals and gives distinct acid fractionation components for calcite and dolomite.

 

The noticed gentler slope of theoretically calculated dolomite-acid digestion curve than of the calcite curve is predicted contemplating the stronger Mg-O bond. Our experimental strategy invokes post-digestion isotopic trade and agrees with the earlier theoretical estimates the place post-digestion isotopic fractionation was thought-about.

 

Mercury isotopes of key tissues doc mercury metabolic processes in seabirds

 

Seabirds accumulate important quantities of mercury (Hg) as a consequence of their long-life span along with their medium to excessive trophic place in marine meals webs. Hg speciation and Hg isotopic analyses of whole Hg in numerous tissues (pectoral muscle tissues, liver, mind, kidneys, blood and feathers) have been assessed to research their cleansing mechanisms.

Three species with contrasted ecological traits have been studied: the Antarctic prion (zooplankton feeder), the white-chinned petrel (pelagic generalist client) and the southern large petrel (scavenger on seabirds and marine mammals). The distinction of mass-dependent fractionation (MDF, δ202Hg) values between liver and muscle tissues (as much as 0.94 ‰) in all three seabirds strongly suggests hepatic demethylation of the isotopically lighter methylmercury (MeHg) and subsequent redistribution of the isotopically heavier fraction of MeHg in direction of the muscle tissues. Equally, greater δ202Hg values in feathers (as much as 1.88 ‰) relative to muscle tissues and better proportion of MeHg in feathers (94-97%) than muscle tissues (30-70%) doubtless point out potential MeHg demethylation in muscle and preferential excretion of MeHg (isotopically heavier) within the rising feathers throughout moult.

The extents of those key cleansing processes have been strongly depending on the species-specific cleansing methods and ranges of dietary MeHg publicity. We additionally discovered greater mass-independent fractionation (MIF, Δ199Hg) values in feathers relative to inner tissues, presumably as a consequence of completely different integration occasions of Hg publicity between completely energetic organs and inert tissues as feathers. Hg isotope variations reported on this examine present proof of cleansing processes in seabirds and suggest a strong strategy for deep investigation of the Hg metabolic processes in seabirds.

Recombinant Human CXCL14 (BRAK)

Z102379 1.0 mg
EUR 3900
Description: Chemokine (CXC motif) ligand 14, also known as breast and kidney-expressed chemokine (BRAK), is a CXC chemokine that is a potent chemoattractant for neutrophils but not for T-cells, B-cells, monocytes or granulocytes. Mature CXCL14 has many conserved features of the CXC family and is 30% homologous to the MIP-α and MIP-β sequences, but differs in that it has an additional five amino acid sequence in between the third and fourth cysteines and a short N-terminus. It is usually highly expressed near its fibroblast source and in epidermal fibroblasts and keratinocytes of skin, but is absent from cancer cells.

BRAK (CXCL14) Human Recombinant

rAP-0116 Inquiry Ask for price

Mouse Monoclonal anti-human CXCL14 (BRAK)

hAP-0213 100ug
EUR 250

Sheep Polyclonal anti-Human CXCL14 (BRAK)

hAP-5820 50ug
EUR 400

Anti-Human BRAK Rabbit Polyclonal Antibody

TA328274 100 µg Ask for price

BRAK

chm-001 5µg
EUR 60
Description: Recombinant Human BRAK (CXCL14)

BRAK antibody

70R-BR016 50 ug
EUR 312
Description: Affinity purified Rabbit polyclonal BRAK antibody

Human CXCL14/BRAK ELISA Kit

E16HE0215 96T
EUR 833.33

Human BRAK (CXCL14) Recombinant Protein

100-139 20 µg
EUR 196.35
Description: Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 alpha and beta. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.

Human BRAK (CXCL14) Recombinant Protein

100-139S 5 µg
EUR 92.4
Description: Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 alpha and beta. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.

Recombinant Human BRAK (CXCL14) Protein

PROTO95715-2 20ug
EUR 380.4
Description: Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 α and β. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.

Recombinant Human CXCL14/BRAK Protein

E40KMP1499 20ug
EUR 495

BRAK (CXCL14) Human Recombinant Protein

PROTO95715 Regular: 20ug
EUR 380.4
Description: CXCL14 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 77 amino acids and having a molecular mass of 9.4kDa.;The CXCL14 is purified by proprietary chromatographic techniques.

Recombinant Human CXCL14/BRAK Protein

RP00348 10 μg
EUR 1137.5

Human BRAK Recombinant Protein Lyophilized

IHUBRAKRLY5UG each
EUR 341
Description: Human BRAK Recombinant Protein Lyophilized

Biotinylated Anti-Human BRAK Rabbit Polyclonal Antibody

TA328273 50 µg Ask for price

BRAK His

chm-239 1µg
EUR 60
Description: Recombinant Human BRAK (CXCL14), His Tag

Recombinant Human BRAK (CXCL14), His Tag

7-01780 5µg Ask for price

Recombinant Human BRAK (CXCL14), His Tag

7-01781 20µg Ask for price

Recombinant Human BRAK (CXCL14), His Tag

7-01782 1mg Ask for price

BRAK protein

30R-AB037 20 ug
EUR 312
Description: Human recombinant BRAK protein

BRAK Human Recombinant (CXCL14), His-Tag

rAP-0119 Inquiry Ask for price

Nori® Human CXCL14/BRAK ELISA Kit

GR106314 96-well
EUR 461

Human BRAK Flow Cytometry Assay - Group 6

HX87213 96 Tests
EUR 270

Recombinant Human BRAK Protein, His, E.coli-1ug

QP11201-1ug 1ug
EUR 186

Recombinant Human BRAK Protein, His, E.coli-5ug

QP11201-5ug 5ug
EUR 241.2

Recombinant Human BRAK Protein, His, E.coli-50ug

QP11201-50ug 50ug
EUR 1513.2

Human, BRAK Human Recombinant Protein (CXCL14), His-Tag

PROTO95715-1 Regular: 5ug
EUR 380.4
Description: CXCL14 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 10.66 kDa. ;The Human BRAK contains a 10 a.a. fusion His tag at N-Terminus. ;The BRAK is purified by proprietary chromatographic techniques.

Recombinant Human BRAK Protein, Untagged, E.coli-1mg

QP10538-1mg 1mg
EUR 3308.4

Recombinant Human BRAK Protein, Untagged, E.coli-5ug

QP10538-5ug 5ug
EUR 186

Recombinant Human BRAK Protein, Untagged, E.coli-20ug

QP10538-20ug 20ug
EUR 241.2

BRAK Recombinant Protein

40-401-0005mg 0.005 mg
EUR 311.1
Description: Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 alpha and beta. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.

BRAK Recombinant Protein

40-401-002mg 0.02 mg
EUR 437.1
Description: Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 alpha and beta. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.

Rat BRAK ELISA Kit

ERB0616 96Tests
EUR 625.2

Goat BRAK ELISA Kit

EGTB0616 96Tests
EUR 625.2

Sheep BRAK ELISA Kit

ESB0616 96Tests
EUR 625.2

Mouse BRAK ELISA Kit

EMB0616 96Tests
EUR 625.2

Breast And Kidney Expressed Chemokine (BRAK) Polyclonal Antibody (Human)

4-PAB607Hu01
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Breast And Kidney Expressed Chemokine (BRAK)

Bovine BRAK ELISA Kit

EBB0616 96Tests
EUR 625.2

Canine BRAK ELISA Kit

ECB0616 96Tests
EUR 625.2

Monkey BRAK ELISA Kit

EMKB0616 96Tests
EUR 625.2

Rabbit BRAK ELISA Kit

ERTB0616 96Tests
EUR 625.2

Chicken BRAK ELISA Kit

ECKB0616 96Tests
EUR 625.2

Porcine BRAK ELISA Kit

EPB0616 96Tests
EUR 625.2

Human Breast And Kidney Expressed Chemokine (BRAK) Protein

20-abx168163
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Anserine BRAK ELISA Kit

EAB0616 96Tests
EUR 625.2

BRAK, CXCL14, murine (mouse)

RC332-25 5ug
EUR 125.26

Human BRAK(Breast And Kidney Expressed Chemokine) ELISA Kit

ELK2082-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human BRAK. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human BRAK. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human BRAK, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human BRAK in the samples is then determined by comparing the OD of the samples to the standard curve.

Human BRAK(Breast And Kidney Expressed Chemokine) ELISA Kit

ELK2082-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human BRAK. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human BRAK. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human BRAK, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human BRAK in the samples is then determined by comparing the OD of the samples to the standard curve.

Recombinant Rat BRAK/CXCL14

RECXP-1401 5ug Ask for price

BRAK (CXCL14) Rat Recombinant

rAP-0118 Inquiry Ask for price

OOPA00002-5UG - BRAK Protein

OOPA00002-5UG 5ug
EUR 70

OPPA01591-5UG - BRAK Protein

OPPA01591-5UG 5ug
EUR 154

BRAK (CXCL14) Mouse Recombinant

rAP-0117 Inquiry Ask for price

Breast And Kidney Expressed Chemokine (BRAK) Polyclonal Antibody (Human), APC

4-PAB607Hu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Breast And Kidney Expressed Chemokine (BRAK). This antibody is labeled with APC.

Breast And Kidney Expressed Chemokine (BRAK) Polyclonal Antibody (Human), Cy3

4-PAB607Hu01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Breast And Kidney Expressed Chemokine (BRAK). This antibody is labeled with Cy3.

Breast And Kidney Expressed Chemokine (BRAK) Polyclonal Antibody (Human), HRP

4-PAB607Hu01-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Breast And Kidney Expressed Chemokine (BRAK). This antibody is labeled with HRP.

Breast And Kidney Expressed Chemokine (BRAK) Polyclonal Antibody (Human), PE

4-PAB607Hu01-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Breast And Kidney Expressed Chemokine (BRAK). This antibody is labeled with PE.

Recombinant Murine BRAK/CXCL14

MECXP-1401 5ug Ask for price

Human Breast And Kidney Expressed Chemokine (BRAK) CLIA Kit

20-abx190238
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Breast And Kidney Expressed Chemokine (BRAK)CLIA Kit

SCB607Hu-10x96wellstestplate 10x96-wells test plate
EUR 6777.36
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK)CLIA Kit

SCB607Hu-1x48wellstestplate 1x48-wells test plate
EUR 663.31
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK)CLIA Kit

SCB607Hu-1x96wellstestplate 1x96-wells test plate
EUR 896.16
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK)CLIA Kit

SCB607Hu-5x96wellstestplate 5x96-wells test plate
EUR 3672.72
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) CLIA Kit

4-SCB607Hu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Breast And Kidney Expressed Chemokine (BRAK)Serum, plasma and other biological fluids

Breast And Kidney Expressed Chemokine (BRAK) Polyclonal Antibody (Human), FITC

4-PAB607Hu01-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Breast And Kidney Expressed Chemokine (BRAK). This antibody is labeled with FITC.

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit

20-abx150834
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Breast and kidney expressed chemokine,BRAK ELISA Kit

201-12-0062 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit

DLR-BRAK-Hu 96T
EUR 443
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit

DLR-BRAK-Hu-48T 48T
EUR 597.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit

DLR-BRAK-Hu-96T 96T
EUR 776.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit

EKL55886-5x96T 5x96T
EUR 3622.83

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit

EKL55886-96T 96T
EUR 762.7

Human Breast and kidney expressed chemokine,BRAK ELISA Kit

EKC40727-48T 48T
EUR 597.24

Human Breast and kidney expressed chemokine,BRAK ELISA Kit

EKC40727-5x96T 5x96T
EUR 4052.7

Human Breast and kidney expressed chemokine,BRAK ELISA Kit

EKC40727-96T 96T
EUR 853.2

Human Breast and kidney expressed chemokine(BRAK) Elisa Kit

EK700372 96 Wells
EUR 0.35

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit

DL-BRAK-Hu 96T
EUR 421
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Breast and kidney expressed chemokine (BRAK) ELISA Kit

EK11048 96Т
EUR 799

Human Breast and kidney expressed chemokine (BRAK) ELISA Kit

AE48297HU-48Tests 48 Tests
EUR 360
Description: Human (Homo sapiens)

 

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